August 31, 2026
For 14 years the best I could offer between an early kidney marker and a retest was the word wait. Then my own cat's SDMA came back elevated and I had to sit with what that word actually feels like.
By Dr. Karen Yamamoto, DVM Holistic Small Animal Practice, Feline Kidney Specialist
August 2026

For 14 years I have told cat owners the same thing when an early SDMA result comes back elevated on an otherwise healthy cat.
Recheck in three to six months. Monitor at home. Call if anything changes.
I said it with confidence because it is the correct clinical recommendation. One elevated SDMA value does not tell you enough on its own. You need a trend. You need time. You need the next panel to compare against.
What I never said out loud, to the owner or to myself, was what bothered me about that recommendation. It was accurate and it was incomplete. Recheck in three to six months tells the owner when to come back. It does not tell the owner what to do in between.
I knew the gap existed. I sent owners home into it hundreds of times. I told myself the gap was the nature of the clinical picture at that stage, that there was nothing evidence-based to fill it with, that the responsible thing was to monitor and wait.
Then my own cat's SDMA came back at 17.

My cat Miso is 12 years old. Domestic shorthair. I have had her since she was four months old. She sleeps on my desk while I write charts and she sits on the exam room counter when I stay late and she has been the most consistent presence in my life for over a decade.
I run her bloodwork myself every six months because I know better than most people what early detection looks like and what it costs when you miss it.
Her panel came back on a Thursday morning while I was between appointments. I pulled it up on the screen the way I pull up every panel, scanning the columns, checking the bars, reading the numbers the way I have read thousands of panels in 14 years of practice.
SDMA 17. Reference range 0 to 14. Everything else normal. Creatinine normal. BUN normal.
If this were a patient's panel I would have picked up the phone and said exactly what I always say. Recheck in three to six months. Monitor at home. Call if anything changes.
Instead I sat at my desk staring at the screen and realized for the first time what that recommendation actually sounds like from the other side of the phone.
It sounds like: we caught something. We do not know what it will do. Come back in a few months and we will find out. In the meantime, do nothing.
I had said that to hundreds of owners. I had never sat with what it feels like to hear it about your own cat.
I did what any vet would do. I went through the supplements I already knew.
I have recommended kidney support products to clients for years. I know the category. I know what is on the shelves. I know the ingredient lists and I know which ones have clinical evidence and which ones are riding on the general reputation of the word kidney support without specifying what they are supporting or how.
I pulled six products off the shelf in my own clinic. I read every label with clinical eyes. Every single one was designed for cats already in the later stages of kidney disease. Appetite support. Energy support. Comfort support. Getting the cat back to eating, back to moving, back to functioning.
All of it was management language. All of it was for cats whose creatinine had already moved, whose kidneys had already lost significant filtration capacity, whose owners were already past the early stretch and into the stage where the goal is quality of life rather than early support.
My cat did not need appetite support. She ate everything in front of her. She did not need energy support. She jumped on my desk every morning at 6 AM. She did not need management. She needed something designed for the stretch she was actually in. The stretch between an elevated SDMA and a retest, when the filtration mechanisms are under early stress and the cat is still completely healthy.
I put all six back on the shelf.
And I stood in my own clinic, with 14 years of feline kidney experience, and realized I had nothing.

The research was there. It had been there for years. I had not looked because I assumed I already knew the category.
I am a holistic feline vet. I work with herbal compounds daily. I evaluate clinical evidence for traditional medicine as part of my practice. I should have been the first person to find what I am about to describe. I was not. I found it three weeks after my own cat's SDMA came back, because my own cat's result forced me to look at the category with different eyes.
Not the eyes of a vet scanning labels on a shelf. The eyes of a cat owner who needs something to exist and cannot find it in the places she has been looking for 14 years.
I went to the published literature. Not the supplement aisle. The peer reviewed research. And I searched for something very specific: compounds with documented activity against the biological mechanisms SDMA is measuring, at the stage when SDMA is elevated but creatinine has not yet moved.

I found four compounds with specific, documented, peer reviewed evidence for kidney filtration support during the early stretch. Not general wellness. Not broad claims. Specific biological activity against the mechanisms SDMA is measuring.
Cordyceps militaris. The Sun et al 2019 study, published in Oxidative Medicine and Cellular Longevity, tracked kidney markers over 3 months. Urinary protein reduced by 36.7%. BUN reduced by 12.5%. Creatinine reduced by approximately 18%. Cystatin C reduced by 14%. Documented activity downregulating inflammatory pathways. These are the specific pathways driving the fibrosis that SDMA catches before creatinine does.
Astragalus root. A Cochrane meta analysis of 22 randomized controlled trials. Not one study. Twenty two. Reviewed kidney filtration and protein levels across thousands of patients. Consistent support signal for glomerular filtration rate and proteinuria markers through TGF beta 1 suppression specifically.
I stopped when I read the Cochrane review. I read it three times. I have been in this field for 14 years and I had never seen a meta analysis of this quality applied to kidney filtration support from herbal compounds. The data was there. It had been there. I had not looked.
Rehmannia root. Active compound catalpol has documented activity on the Nrf2 pathway for renal cell protection in preclinical research. The caution is clear: Rehmannia may have a mild blood sugar lowering effect, so it should be used with caution in diabetic cats or cats on blood sugar medication.
Dong Quai root. Evidence from a longitudinal cohort study showing reduced risk of kidney disease progression. Mild blood thinning properties, which is why it is not appropriate for cats on amlodipine, heart medication, or blood thinners without vet approval.
Four compounds. Four documented mechanisms. All of them mapped to the specific biological processes SDMA is measuring. None of them designed for late stage management. All of them targeted at the early stretch, when filtration is under stress but the cat is still healthy and the standard protocol has no action step.
I had seen some of these herbs in other kidney formulas on my own shelf. But those formulas used them at different dosages, in different ratios, for a different purpose. They were built for cats further along. What I had not seen was these four combined specifically for the biological processes SDMA is measuring, at the stage when SDMA is elevated and everything else is still normal.
I searched for a formula that combined all four at the documented dosages, in the forms the research used, with sourcing documentation rather than just ingredient names on a label.
I found one. A liquid formula. Bacon flavored. Delivered by dropper into wet food, twice a day. It is called KindPaws Kidney Function Support.
Before I would consider offering it to any patient, I needed to use it myself. On my own cat. That is the standard I hold for anything I bring into my practice. If I would not use it on Miso, I will not recommend it to your cat.

I drew the amount up carefully and set it into her wet food and mixed it once with the tip of a spoon. She walked over. Sniffed the dish for about a second. Ate the entire bowl.
That mattered to me clinically. Whether a cat will actually eat the food is the first thing that has to work. If the cat refuses it, nothing else matters. She did not refuse.
I kept the routine for the months between the result and the retest. Twice a day. Every day. Morning and evening. I put a note on her chart in my own system the way I would for any patient: formula started, date, dose, twice daily..
I ran the panel myself. I stood at the screen and read the numbers the way I have read thousands of panels.
SDMA stable. Creatinine still normal. The number held.
I sat down and closed Miso's chart and sat with it for a minute. Not as a vet reading a panel. As an owner seeing the number she was afraid of hold steady instead of climb.
Stable is the honest goal here. Not reversal. Not restoration. Stable means the number did not move in the wrong direction during a stretch of time when it easily could have. As a vet, I know what stable means at this stage. As an owner, I know what it feels like.
I am continuing the formula. Miso is on it every morning and every evening. This is not something I am using for one retest cycle. This is her ongoing daily routine.

After Miso's retest I started showing the research to select clients. Not recommending a product. Showing the published studies and letting them evaluate.
The clients I showed it to first were the ones I recognized. The ones who sat in the chair across from me with the same expression I saw in my own face the morning I read Miso's panel. The ones who heard me say recheck in three to six months and I could see the question they were not asking: what do I do until then.
I started offering the research alongside the recheck recommendation. The Cochrane review on Astragalus. The Cordyceps militaris data. The preclinical research on Rehmannia. I explained what the compounds target, why they map to what SDMA is measuring, and what stable at retest looks like as an honest clinical outcome.
I have now seen stable SDMA retests in multiple patients whose owners used this formula during the months between the initial result and the recheck. I am not describing that as a clinical trial. I am describing it as a consistent observation in my practice from owners who chose to use something evidence-based during a stretch when the standard protocol offered nothing.
A client named Margaret came in six months ago with a 13 year old tabby whose SDMA came back at 18. Everything else normal. I gave her the standard recommendation, and I also showed her the research.
She read the Cochrane review summary in my exam room. She asked me two questions. She asked if I had used it on my own cat. I said yes. She asked what the retest showed. I said stable.
She ordered it that evening.
At the retest her cat's SDMA was stable. Creatinine still normal. She sat in the chair across from me and said something I have thought about every day since.
She said: "You circled a number I had never seen before and then you handed me something real to do about it. Six months later I am sitting here and the number held. I do not have words for what that feels like."
That is why I am writing this. Not to sell a product. To close the gap I have been sending owners into for 14 years.

SDMA catches kidney filtration stress earlier than creatinine. By the time creatinine rises on a standard panel, approximately 75% of filtration function has already declined. SDMA picks up the signal at 25 to 40% of filtration under stress. That is the difference between catching something early and catching it late.
The months between an elevated SDMA and the next retest are the months when the filtration mechanisms are under stress but the cat still looks completely healthy. The standard protocol for that stretch is to monitor and recheck. That protocol is correct. It is also incomplete. It tells you when to come back. It does not give you anything to do in between.
What drives filtration decline during the early stretch is primarily TGF beta 1 mediated renal fibrosis. The progressive replacement of healthy kidney tissue with scar tissue. The compounds I described above have documented activity against that specific pathway. They are not general wellness. They are mechanism-specific early support.
If your cat's SDMA came back elevated and your vet said recheck in three to six months, the vet is right. Follow that recommendation. But also know that the months between now and that recheck do not have to be empty. The research exists. The formula exists. Your vet can review it.

KindPaws offers a 90 day money back guarantee. If your cat will not take it, if your retest does not hold steady, or if you simply decide the answer was no, you get a full refund, no questions asked.
The Dong Quai safety note: do not use if your cat is on amlodipine, heart medication, or blood thinners without vet approval. The Rehmannia note: use with caution in diabetic cats or cats on blood sugar medication. Those disclosures are there because the formula was built for a specific stage, not for the general kidney supplement category.
This formula is designed to work alongside the vet protocol, not instead of it.
"My vet told me to recheck in three months and I spent the first two weeks doing nothing but worrying. I found KindPaws through a holistic vet post about early kidney markers. My cat took the drops without noticing. Retest came back stable. I brought the label to my vet afterward and she said she had no concerns for my cat's situation. Continuing it."
- Carolyn D., 57, verified purchaser
"When my cat's SDMA came back elevated I searched for weeks. Everything I found was for cats already in decline. Mine was perfectly healthy. KindPaws was the only thing I found built for the early stretch specifically. Four months in, two retests, both stable. My vet reviewed the research and said to keep going."
- Patricia L., 64, verified purchaser
"I am the kind of person who reads every study before I give my cat anything. I read the Cochrane review on Astragalus and the Cordyceps research before I ordered. The mechanism is specific and it matched what my vet explained SDMA is measuring. Retest stable. The dropper takes four seconds. She does not notice it in her food."
- Nancy K., 61, verified purchaser
Order KindPaws Kidney Function Support here while stock lasts and start it in tomorrow morning's food.
The ninety days are already running.


Four research backed herbs targeting the specific kidney filtration processes your cat's SDMA result is measuring. Delivered by dropper into wet food, twice a day. A cat will actually take them.
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